Agenda

The first day starts with a review of current research on early AD diagnosis and biological characterization from a clinical, biological and computational side. Importantly, we see the challenge of early diagnosis from a technology agnostic point of view. That means, the focus is not only on blood-based biomarkers, but also includes modern digital device technology, which could be potentially used in an at-home setting to monitor cognitive function, sleep disturbances or behavior and may thus serve as “digital” markers of disease associated symptoms. The program at the first day is divided into four sessions.

Day 1 (25 June 2025)
08.15 – 08.45 Arrival and welcome
08.45 – 09.00 Introduction and overview about ADIS
Holger Fröhlich, Fraunhofer SCAI
09.00 – 11.00 Session 1: Early Diagnosis of Alzheimer’s Disease – The Perspective
(Chair: Holger Fröhlich)

  • Overview about the ADIS clinical study – Raquel Sanchez-Valle, Hospital Clinic Barcelona
  • IHI project PREDICTOM – Dag Aarsland, Kings College London
  • IHI project AD-RIDDLE – Miia Kivipelto, Karolinska Institutet
  • IHI project PROMINENT – Linus Jönsson, Karolinska Institutet
11.00 – 11.30 Coffee break
11.30 – 12.15 Session 2: Immune Profiling and Single Cell Sequencing of Blood Cytotoxic Lymphocytes
(Chair: Neus Fálgas*)

  • Invited talk DZNE project – Joachim Schulze, DZNE
  • Single cell sequencing and statistical analysis in ADIS – Stefan Kirsch, Fraunhofer ITEM; István Nagy, SeqOmics
  • Immune profiling in ADIS – Kuti Baruch, ImmunoBrain Checkpoint
13.15 – 14.30 Lunch break
14.30 – 15.15 Session 3: AI and Agent-Based Modeling for Biomarker Discovery and Risk Profiling
(Chair: Kuti Baruch)

  • Invited talk – Anna Bauer-Mehren, Roche Diagnostics
  • AI based modeling of ADIS scRNAseq data – Sophia Krix*, Fraunhofer SCAI
  • Agent Based Modeling of ADIS data – Uri Nevo / Liad Doniza*, Tel Aviv University
16.15 – 16.45 Coffee break
16.45 – 18.15 Session 4: Digital Biomarkers
(Chair: Stefan Kirsch)

  • Altoida and its application to ADIS – Florentia Iulita, Altoida; Sophia Krix*, Fraunhofer SCAI
  • AI based modeling of sleep in ADIS – Sophia Krix*, Fraunhofer SCAI
  • Behavioral monitoring via the BHQ app – Uri Nevo, Tel Aviv University
19.00 Working dinner

Remark: Speakers marked with *) are considered as early career professionals, i.e. PhD candidates or young professionals with less than 6 years of job experience.

The second day is devoted to discussing existing research on disease prevention strategies and round table discussions on possible next steps and collaboration opportunities.

Day 2 (26 June 2025)
09.00-10.30 Session 5: From Early Diagnosis to Disease Prevention
(chair: Raquel Sanchez)

  • Invited talk – David Bartrés-Faz, University of Barcelona
  • PatternCog project – Ruth Steven *), Karolinska Institutet
  • Towards developing a targeted disease prevention strategy in ADIS – Soraya Moradi-Bachiller, Alzheimer Europe
Coffee break 10.30 – 11.00
11.00 – 13.00 Round table discussion 1
(parallel break-out sessions – moderator: Holger Fröhlich)
Addressing the big challenges in AD
Lunch break 13.00 – 14.30
14.30 – 16.30 Round table discussion 2
(joint discussion – moderator: Uri Nevo)
Reporting from break-out sessions
16.30 – 17.00 Wrap-up and planning of next steps – Uri Nevo, Tel Aviv University